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上海j9九游生物科技有限公司努力于表观遗传学在迷信研讨和临床检测上的使用,是上海市高新技能企业,博士后创新理论基地。在科研办事范畴,团队次要产品线有CUT&Tag/ChIP-seq,ATAC-seq,1微克MeRIP-seq, eccDNA-seq(环状DNA测序),单细胞ATAC-seq和单细胞RNA-seq。

       j9九游生物的ChIP-seq技能帮忙客户宣布论文十余篇,所宣布的杂志包罗Nature Communications,PNAS和Theranostics等;2018年8月1日j9九游生物公布了十万样本ATAC-seq测序方案,该方案遭到北京大学李程传授,和同济大学江赐忠传授的高度点评;2019年1月,j9九游生物的ATAC-seq实行技能帮忙客户于The Journal of Clinical Investigation宣布论文Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer,影响因子12.282分;2019年3月,j9九游生物经过了美国10X Genomics 公司的单细胞ATAC-seq产品线的CSP认证2020年6月,j9九游生物帮忙客户在Molecular Therapy: Nucleic Acids影响因子7.032,连发2篇MeRIP-seq文章。别的,2018年9月,j9九游生物于Plos  Biology杂志宣布1微克RNA的MeRIP-seq实行文章 Refined RIP-seq protocol for epitranscriptome analysis with low input materials,开启了MeRIP-seq技能进入临床医学研讨的尾声。


j9九游生物到场宣布的文章列表//article

人和植物的文章:        

[1] Yu S H, Zhu K Y, Chen J, et al. JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML[J]. Nature Communications, 2018. (IF: 12.353)
[2] Ho J W K, et al. Comparative analysis of metazoan chromatin organization[J]. Nature, 2014, 512(7515): 449. (IF: 40.136)
[3] Yamamoto S, et al. JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer[J]. Cancer Cell, 2014, 25(6): 762-777. (IF: 27.407)
[4] Ouyang Q, et al. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesis in Liver Regeneration and Hepatocarcinogenesis[J]. Hepatology, 2017, 67(3).(IF: 13.246)
[5] Fulciniti M, et al. Integrating Gene and Mir Expression Profiles and Regulatory Network Structures to Define Aberrent Feed Forward Loops with Functional and Clinical Implications in Myeloma [M]. Am Soc Hematology. 2012. (IF: 12.595)
[6] Du Z, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer[J]. Nature Structural & Molecular Biology, 2013, 20(7): 908-13. (IF: 12.595)
[7] Wang X, et al. Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma[J]. Leukemia, 2014, 28(4): 894-903. (IF:12.104)
[8] Wang C, et al. Computational inference of mRNA stability from histone modification and transcriptome profiles[J]. Nucleic acids research, 2012, 40(14): 6414-6423. (IF: 10.162)
[9] Dai Y J, Wang Y Y, Huang J Y, et al. Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement[J]. Proceedings of the National Academy of Sciences, 2017, 114(20): 5237-5242. (IF: 9.504)
[10] Lin X, et al. BSeQC: quality control of bisulfite sequencing experiments[J]. Bioinformatics, 2013, 29(24): 3227-3229. (IF: 7.307)
[11] Sun H, et al. CistromeFinder for ChIP-seq and DNase-seq data reuse[J]. Bioinformatics, 2013, 29(10): 1352. (IF: 7.307)
[12] Zeng W, et al. Distinct Transcriptional and Alternative Splicing Signatures of Decidual CD4+ T Cells in Early Human Pregnancy[J]. Frontiers in Immunology, 2017, 8(IF:6.4)

[13] Kong X, Wei G, Chen N, Zhao S, Shen Y, Zhang J, Li Y, Zeng X, Wu X. Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection. PLoS Pathog. 2020 Jun 8;16(6):e1008633. (IF:6.218)
[14] Liu X Z, et al. All-transretinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells[J]. Cell Death & Disease, 2017, 8(5): e2782. (IF:5.965)

[15] Wang J, et al. PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression[J]. Scientific Reports, 2014, 4(6186): 5008. (IF:4.259)
[16] Ling Y, et al. ProFITS of maize: a database of protein families involved in the transduction of signalling in the maize genome[J]. Bmc Genomics, 2010, 11(1): 580. (IF: 3.729)
[17] Li Y, et al. Classify Hyperdiploidy Status of Multiple Myeloma Patients Using Gene Expression Profiles[J]. Plos One, 2013, 8(3): e58809. (IF:2.806)
[17] Zhang J , Wang C , Chen X , et al. EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast?cancer[J]. The EMBO Journal, 2015, 34(23):2953-2970. (IF: 10.557)
[19] Ding Y, Li N, Dong B, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer[J]. The Journal of clinical investigation, 2019, 129(2). (IF:12.282)
[20] Zhang W, Zhao C, Zhao J, et al. Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival[J]. Theranostics, 2018, 8(16): 4359. (IF: 8.537)

[21] Yang J, Liu J, Zhao S, Tian F. N6-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. Mol Ther Nucleic Acids. 2020 Jun 5;20:111-116.(IF:7.032)

[22] Zhao W, Cui Y, Liu L, Ma X, Qi X, Wang Y, Liu Z, Ma S, Liu J, Wu J. METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification. Mol Ther Nucleic Acids. 2020 Jun 5;20:1-12. (IF:7.032)
[23] Hua X, Xiong J W, Zhang Y J, et al. Exposure of pregnant mice to triclosan causes hyperphagic obesity of offspring via the hypermethylation of proopiomelanocortin promoter[J]. Archives of toxicology, 2019, 93(2): 547-558. (IF: 5.741)
[24] Song SY, Meng XW, Xia Z, et al.Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane[J]. Aging,2019 ,11(19):8386-8417. (IF:5.515)
[25] Wang Y., Zhang X., Song Q. et al. Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model. Alz Res Therapy 12, 29 (2020).



动物和真菌的文章:         

[1] Yi X, et al. PlantGSEA: a gene set enrichment analysis toolkit for plant community[J]. Nucleic Acids Research, 2013, 41(Web Server issue): 98-103. (IF: 10.162)
[2] Du Z, et al. agriGO: a GO analysis toolkit for the agricultural community[J]. Nucleic Acids Research, 2010, 38(Web Server issue): W64. (IF: 10.162)
[3] Du Z, et al. Genome-wide analysis of histone modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica[J]. Molecular plant, 2013, 6(5): 1463-1472. (IF:8.827)
[4] Hale C J, et al. Identification of multiple proteins coupling transcriptional gene silencing to genome stability in Arabidopsis thaliana[J]. PLoS genetics, 2016, 12(6): e1006092. (IF:6.1)
[5] Su Z, et al. plantsUPS: a database of plants' Ubiquitin Proteasome System[J]. Bmc Genomics, 2009, 10(1): 227. (IF: 3.729)
[6] Yang C, et al. Integration of ATAC-Seq and RNA-Seq Identifies Key Genes in Light-Induced Primordia Formation of Sparassis latifolia [J]. International Journal of Molecular Sciences, 2020, 21, 185. (IF: 4.183)


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